Infections caused by anaerobic bacteria are common, and may be serious and life-threatening. Anaerobes predominant in the bacterial flora of normal human skin and mucous membranes, and are a common cause of bacterial infections of endogenous origin. Infections due to anaerobes can evolve all body systems and sites. The predominate ones include: abdominal, pelvic, respiratory, and skin and soft tissues infections. Because of their fastidious nature, they are difficult to isolate and are often overlooked. Failure to direct therapy against these organisms often leads to clinical failures. Their isolation requires appropriate methods of collection, transportation and cultivation of specimens. Treatment of anaerobic bacterial infection is complicated by the slow growth of these organisms, which makes diagnosis in the laboratory only possible after several days, by their often polymicrobial nature and by the growing resistance of anaerobic bacteria to antimicrobial agents.

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Sunday, March 2, 2014

Periodontal pathogens ( Porphyromonas gingivalis and Fusobacterium nucleatum) may promoting oral cancer ( Kaposi's sarcoma)

Kaposi's sarcoma  (KS) is a tumor caused by human herpesvirus 8 (HHV8, also known as Kaposi's sarcoma-associated herpesvirus, KSHV).  About 20% of HIV patients develop Kaposi's sarcoma (KS) lesions in the oral cavity while other patients never develop oral KS. It is not known if the oral micro environment plays a role in oral KS tumor development.

Xiaolan and colleagues from Case Western Reserve University, Cleveland, Ohio demonstrated that a group of metabolic by-products (short chain fatty acids), from bacteria that cause periodontal disease (Porphyromonas gingivalis and Fusobacterium nucleatum) promote lytic replication of KSHV. These new findings provide mechanistic support that periodontal pathogens create a unique micro environment in the oral cavity that contributes to KSHV replication and development of oral KS. However, more research is needed to find out if patients with KS suffer more often from periodontal disease and exhibit higher levels short chain fatty acids produced by the periodontal pathogens.

oral cavity Kaposi's sarcoma